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Image Search Results
Journal: The Journal of International Medical Research
Article Title: Pachymic acid alleviates lipopolysaccharide-induced cystitis glandularis by inhibiting ferroptosis
doi: 10.1177/03000605251396755
Figure Lengend Snippet: Therapeutic effect of PA on LPS-induced CG. (a) Histopathological sections of bladder tissues from each group were observed via H&E staining. The magnified regions revealed the epithelial layer of the bladder. In the LPS group, distinct formation of Brunn’s nests was observed, accompanied by epithelial edema and increased inflammatory cell infiltration. Following treatment with Fer-1 and PA, Brunn’s nests disappeared, epithelial edema was alleviated, and inflammatory cell infiltration was reduced (Scale bar = 100 μm). (b) At 400× magnification, histopathological features across multiple fields of view were observed. The severity of inflammation was scored and visualized as a heatmap, where columns represent three individual animals per group, and rows correspond to five distinct microscopic fields from each animal. Additionally, statistical analysis of the inflammatory scores was performed. (c) to (e) Levels of IL-1β, IL-6, and TNF-α in bladder tissues from each group of rats. The above data are presented as mean value ± SD, ns means p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001. CG: cystitis glandularis; H&E: hematoxylin and eosin; LPS: lipopolysaccharide; PA: pachymic acid.
Article Snippet:
Techniques: Staining